Jobs in Structural Biology and Related Fields


Scientific Software Developer, Cryo-EM


Astex Pharmaceuticals, Cambridge , United Kingdom
Application deadline: 09 May 2024


We are looking for a talented Scientific Software Developer to join our cryo-EM software team, based in Cambridge, UK. The core responsibility of the cryo-EM software team is the development and maintenance of webcryo, our proprietary, high-throughput cryo-EM data processing and visualisation platform. Serving as the backbone for all of Astex’s cryo-EM structure- and fragment-based drug discovery projects, webcryo plays a critical role in the operation of our electron microscope facility. The platform features automated data processing pipelines, web-based analysis tools, and seamless integration with our corporate database, which tracks all experimental workflows, including sample purification, preparation, and processing.

You will initially work on building tools to help Astex scientists determine protein-ligand structures using cryo-EM. Our core software stack includes Python, HTML, JavaScript, RESTful APIs and Git (with Gitlab). These are complemented by components like Python-based web frameworks (Flask and FastAPI), relational databases (Oracle), user interface libraries (React), visualisation libraries (Bokeh) and containerisation (Docker) and you will ideally have some experience in one or more of these technologies. There will also be the opportunity to contribute to scientific software development efforts within the wider Molecular Sciences and Informatics departments and you will be expected to communicate and operate collaboratively across various disciplines and project teams.

If you are interested or have any questions, please don’t hesitate to get in touch with Michael Saur (Michael.saur@astx.com) or Pamela Williams (pamela.williams@astx.com). Alternatively, please visit the website.