Centres - Instruct-ERIC

The Instruct Centre at EMBL Grenoble provides access to automated protein-to-structure and fragment screening crystallography pipelines

The Instruct Centre EMBL Grenoble is a key player in the Partnership for Structural Biology (PSB) through which the Grenoble European Photon and Neutron (EPN) Campus institutes – EMBL, the European Synchrotron Radiation Facility (ESRF), the Institut Laue-Langevin, and the Institut de Biologie Structurale (IBS) – provide a uniquely comprehensive range of structural biology platforms for sample production, sample characterization and structure determination. EMBL Grenoble operates the High Throughput Crystallization Facility (HTX lab). This facility offers access to fully automated, remote controlled crystallography pipelines based on the CrystalDirect technology and the CRIMS software. Data collection is carried out at the ESRF MX beamlines operated by the ESRF- EMBL Joint Structural Biology Group. EMBL Grenoble is also a partner in FRISBI (French Infrastructure for Structural Biology). Instruct access opportunities at EMBL Grenoble include:

• High throughput crystallization

• Online Crystallography (protein-to-structure pipeline)

• Fragment Screening

• Screening and structural characterization of ligand-target complexes

71 avenue des Martyrs

38042, Grenoble

EMBL

EMBL Grenoble website

Visitor information

EMBLGrenoble is located at the EPN campus in Grenoble, France. Convenient shuttle bus connections to Lyon and Geneva airports area available. Site entry has to be arranged before your visit.
For more information on how to reach EMBL please visit https://www.embl.fr/aboutus/contact/travel/index.html

Flagship Service/Technology at EMBL Grenoble:

EMBL Grenoble offers access to a fully automated protein to structure pipeline based on the CrystalDirect technology an the CRIMS software. Starting from purified samples, this pipeline integrates automated crystallization screening, crystal growth optimisation, automated crystal harvesting and cryocooling and X-ray diffraction data collection in a continuous and fully automated workflow operated over the Internet.

Other Services/Technologies at EMBL Grenoble:

EMBL Grenoble offers access to automated nano-volume crystallization screening and optimization services. Additional services include sample quality assessment and buffer optimization through TSA and estimation of crystallization likelihood. This platform is remotely operated through the web via the Crystallographic Information Management System (CRIMS) providing real-time access to results and experimental parameters.

Publications

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- EMBL Grenoble

Visitor information

Flagship Service/Technology at EMBL Grenoble:

X-ray Diffraction, Grenoble, EMBL

Other Services/Technologies at EMBL Grenoble:

Publications